With a Much Less Favorable Outcome
As before, you'll need to walk up to the yellow "X" and mingle with the crowd that has gathered to hear Nigel's spiel. Mr. West Dickens extols the virtues of his worthless tonic, and a pair of riders appear who were previously swindled by Nigel. They're unimpressed with the effectiveness of his tonic and their words quickly turn the crowd against the two of you.
Run back to the wagon with Nigel and hop up into the shotgun position. The former customers are very angry and out for blood, so you'll have to take them out to survive. Much like the first time you met Nigel, you'll need to shoot and escape at the same time, only this time you don't have to drive while you do so.
A series of riders will appear as Nigel drives the wagon, and you'll need to take them out quickly before either John or Nigel are injured. Watch the radar to spot them as they approach, and take them out from as long a distance as possible.
As you near the railroad tracks, you'll come across a blockade in the road ahead. Shoot the TNT in the wagon ahead to clear the road, and take out the gunner stationed atop a nearby rock. As you pass Benedict Point, a gunman in a wagon will approach. Take them out as quickly as you have all the other attackers.
The two of you won't be safe until you reach Cueva Seca, so keep your gun at the ready and continue to take out any bad guys who come near until you arrive.
Afterward, John is none too happy with Nigel for getting him involved in another scheme and for putting his life in jeopardy once again. After a few choice words, the mission ends and you'll earn some fame for your efforts.
For more mission walkthroughs, cheat codes, weapons guides, and more, check out our Ultimate Guide to Red Dead Redemption.