Everybody Was Kung-Fu Fighting
You've got your steady supply of blood worked out, but what do you do when challenged by enemies? You'll find that fighting in this game can be quite entertaining. Unlike the usual point-and-click attacks of some games, there actually are some differences in how you attack. There are a multitude of weapons, and each one has its benefits and drawbacks. You don't usually want to pull out a weapon and start swinging it around in public. But what you can do is find an empty apartment and practice. With guns, its obvious what the result is, so no sense in wasting the bullets. But you also get some interesting melee weapons, and you should get to know them well. The fireman's axe in particular, is a incredibly devastating weapon. In a hand-to-hand fight, this one can end it quickly. It works exceptionally well against other vampires.
One thing to note is that when you move your character in different directions while attacking, different things happen. For example, when you move sideways while striking with the axe, you get a different attack than when you just stand there and swing away. This is a great way to be a moving target as well as hit your enemy in unique ways. The AI of the game does pay attention, so if you keep attacking the same way, the enemy will be harder to kill. Make your combat unexpected by not doing the same thing over and over.
The next question is which weapon should you use in which scenario? To understand this, you need to understand how combat works in this game. Armor - in this game, clothing - provides defense or soak value. When an attack needs to get through armor, it has to get through the soak value. The better your armor is obviously, the higher your soak value. Vampires and other supernatural creatures can soak Lethal damage types as well, such as bullets. For that matter, bullets are considered Lethal damage to humans but only Bashing damage to vampires. And vampires reduce all Bashing damage by 50% after soak as well. Aggravated damage can only be soaked by Fortitude, so you may want to get that particular attribute higher for your own protection.
You have to check out a weapon's stats to judge whether its good in a certain scenario. As you can see from above, vampires and other supernaturals will be your toughest foes. But humans can still take you down if you don't watch out. You want to pay attention to the Lethality value, the Damage Type, and the Speed of each weapon. Bladed weapons usually do better against vampires than bullets do, and fire is by far the best. Blocking can be an effective tool in this game, but not being there when the attack happens is the best option. Yes, dodging actually works and can be very useful. There are also weapons that do Knockback too, so utilize those when the time feels right.
Lastly, there are certain Disciplines that can help out with your combat effectiveness. Some can make you completely invisible, allowing you to sneak up on your foe. Others give you more Strength or Dexterity, while still others enhance your defenses. Your Disciplines depend upon what clan you are a part of, so you'll want to choose wisely which clan to join at the beginning. This does not mean however that you have unlimited power to bend the world to your will. Disciplines all have a cost in blood points, so be selective in their use. It does no good to have the highest level in a Discipline if you don't have the blood points to utilize it.